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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
27/01/2020 |
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Actualizado : |
27/01/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
ESCRIBANO, C.; SARAVIA, A.; COSTA, M.; CASTELLS, D.; CIAPPESONI, G.; RIET-CORREA, F.; FREIRE, T. |
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Afiliación : |
CECILIA ESCRIBANO, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MONIQUE COSTA, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; DANIEL CASTELLS, Secretariado Uruguayo de Lana, Florida, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESA FREIRE, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. |
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Título : |
Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Scientific Reports, 1 December 2019, Volume 9, Issue 1, Article number 19579. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-019-55447-6 |
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ISSN : |
2045-2322 |
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DOI : |
10.1038/s41598-019-55447-6 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 21 June 2019 / Accepted: 27 November 2019 / Published: 20 December 2019.
Funding information:
We acknowledge the personnel from Uruguayan Wool Secretariat that assisted with animal studies. This project was funded by INIA (Uruguay) and CSIC-VUSP (Uruguay). C.E. was funded by a scholarship by INIA. |
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Contenido : |
ABSTRACT.
Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks.
© 2019, The Author(s). |
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Palabras claves : |
HAEMONCHUS; SHEEP. |
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Asunto categoría : |
L01 Ganadería |
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URL : |
https://www.nature.com/articles/s41598-019-55447-6.pdf
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Marc : |
LEADER 02635naa a2200253 a 4500
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008 2019 bl uuuu u00u1 u #d
022 $a2045-2322
024 7 $a10.1038/s41598-019-55447-6$2DOI
100 1 $aESCRIBANO, C.
245 $aResistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response.$h[electronic resource]
260 $c2019
500 $aArticle history: Received: 21 June 2019 / Accepted: 27 November 2019 / Published: 20 December 2019. Funding information: We acknowledge the personnel from Uruguayan Wool Secretariat that assisted with animal studies. This project was funded by INIA (Uruguay) and CSIC-VUSP (Uruguay). C.E. was funded by a scholarship by INIA.
520 $aABSTRACT. Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks. © 2019, The Author(s).
653 $aHAEMONCHUS
653 $aSHEEP
700 1 $aSARAVIA, A.
700 1 $aCOSTA, M.
700 1 $aCASTELLS, D.
700 1 $aCIAPPESONI, G.
700 1 $aRIET-CORREA, F.
700 1 $aFREIRE, T.
773 $tScientific Reports, 1 December 2019, Volume 9, Issue 1, Article number 19579. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-019-55447-6
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela; INIA Las Brujas; INIA Tacuarembó. |
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Fecha actual : |
21/02/2014 |
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Actualizado : |
24/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Agropecuarias |
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Autor : |
DE LUCCA, R.; ZEBALLOS, R.; GRECCO, H.; SORIA, J.; PISANO, J. |
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Afiliación : |
REINALDO DE LUCCA; ROBERTO ZEBALLOS; HÉCTOR GRECCO; JORGE RAUL SORIA BARAIBAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JULIO CESAR PISANO CARBAJAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Pavía Sauce, Moscato Rojo y Moscato Blanco: nuevas variedades de duraznero creados en Uruguay por la DIGEGRA y el INIA |
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Fecha de publicación : |
2008 |
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Fuente / Imprenta : |
Revista INIA, 2008, no. 16, p.26-28 |
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ISSN : |
1510-9011 |
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Idioma : |
Español |
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Palabras claves : |
MOSCATO ROJO. |
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Thesagro : |
DURAZNERO; DURAZNO; MOSCATO BLANCO; PAVÍA SAUCE; VARIEDADES. |
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Asunto categoría : |
--
A50 Investigación agraria |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/935/1/18429050209150235.pdf
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Marc : |
LEADER 00661naa a2200241 a 4500
001 1013131
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008 2008 bl uuuu u00u1 u #d
022 $a1510-9011
100 1 $aDE LUCCA, R.
245 $aPavía Sauce, Moscato Rojo y Moscato Blanco$bnuevas variedades de duraznero creados en Uruguay por la DIGEGRA y el INIA
260 $c2008
650 $aDURAZNERO
650 $aDURAZNO
650 $aMOSCATO BLANCO
650 $aPAVÍA SAUCE
650 $aVARIEDADES
653 $aMOSCATO ROJO
700 1 $aZEBALLOS, R.
700 1 $aGRECCO, H.
700 1 $aSORIA, J.
700 1 $aPISANO, J.
773 $tRevista INIA, 2008, no. 16, p.26-28
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INIA Las Brujas (LB) |
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